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KMID : 0670820090140040177
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Korean Journal of Medical Mycology
2009 Volume.14 No. 4 p.177 ~ p.181
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Study of Empirical Antifungal Therapy in Febrile Neutropenia and Invasive Fungal Infection after Introduction of Novel Antifungal Agents
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Lee Eun-Jung
Kim Tae-Hyong
Choo Eun-Ju
Jeon Min-Hyok
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Abstract
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Background: Patients with prolonged empirical broad spectrum antibiotics for febrile neutropenia (FN) with cancer, inevitably have increased risk of invasive fungal infections owing to the altered endogenous microbial environment.
Objective: The purpose of this study is to evaluate the impact of empirical antifungal therapy on occurrence of invasive fungal infections (IFIs) during FN with cancer.
Methods: We retrospectively reviewed medical records of patients with FN after cytotoxic chemotherapy due to cancer from July, 2003 to June, 2007.
Results: We identified 91 patients with FN after cytotoxic chemotherapy. Most common underlying conditions were lymphoma (20/91, 22%) and leukemia (20/91, 22%). IFIs occurred in 10% (9/91). In a comparison of patients with empirical antifungal therapy with no antifungal therapy, the duration of neutropenia was significantly increased with IFIs (p=0.09). The mortality of IFIs was 55.5% (5/9).
Conclusion: We found that the duration of FN than empirical antifungal therapy affected occurrence of IFIs.
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KEYWORD
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Empirical antifungal therapy, Febrile neutropenia
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